1 An Increase in Persistent Sodium Current Contributes to Intrinsic 2 Neuronal Bursting After Status Epilepticus 3 4 5
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چکیده
An Increase in Persistent Sodium Current Contributes to Intrinsic 2 Neuronal Bursting After Status Epilepticus 3 4 5 Shmuel Chen, Hailing Su, Cuiyong Yue, Stefan Remy, Michel Royeck, Dmitry 6 Sochivko, Thoralf Opitz, Heinz Beck and Yoel Yaari 7 8 9 Department of Medical Neurobiology, Institute of Medical Research Israel-Canada, 10 Hebrew University-Hadassah School of Medicine, Jerusalem, Israel 11 Department of Epileptology, University of Bonn Medical Center, D-53105 Bonn, 12 Germany 13 The Interdisciplinary Center for Neuronal Computation, the Hebrew University, 14 Jerusalem 91904, Israel 15 16 Running title: Persistent Na current in epileptogenesis 17
منابع مشابه
An increase in persistent sodium current contributes to intrinsic neuronal bursting after status epilepticus.
Brain damage causes multiple changes in synaptic function and intrinsic properties of surviving neurons, leading to the development of chronic epilepsy. In the widely used pilocarpine-status epilepticus (SE) rat model of temporal lobe epilepsy (TLE), a major alteration is the marked increase in the fraction of intrinsically bursting CA1 pyramidal cells. Here we have differentiated between two t...
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Most types of electrographic epileptiform activity can be characterized by isolated or repetitive bursts in brain electrical activity. This observation is our motivation to determine mechanisms that underlie bursting behavior of neuronal networks. Here we show that the persistent sodium (Na(P)) current in mouse neocortical slices is associated with cellular bursting and our data suggest that th...
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A single episode of status epilepticus (SE) causes numerous structural and functional changes in the brain that can lead to the development of a chronic epileptic condition. Most studies of this plasticity have focused on changes in excitatory and inhibitory synaptic properties. However, the intrinsic firing properties that shape the output of the neuron to a given synaptic input may also be pe...
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تاریخ انتشار 2010